This letter, signed by various trade associations representing a wide range of industries, urges key federal agencies to support efforts to bring transparency, predictability, and fairness to the standard-essential patent (SEP) licensing ecosystem. It highlights the imbalance and unfairness in the current global SEP licensing system, particularly driven by practices in the European Union (EU), which expose American companies to litigation and uncertainties. The letter supports the EU’s proposed SEP licensing regulation as a step towards improvement and calls for rejecting assertions by certain special interests against it. It urges support for creating a more transparent, predictable, and fair SEP licensing environment and offers collaboration in advancing competitiveness.